The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells
Summary Gly‐Pro‐Ala‐Gly‐Pro‐His‐Gly‐Pro‐Pro‐Gly ( GPAGPHGPPG ), a chelating peptide derived from Alaska pollock skin, has been approved with outstanding ability to chelate calcium, zinc and iron ions. In this study, the stability of GPAGPHGPPG during in vitro g astrointestinal enzymatic digestion, t...
Published in: | International Journal of Food Science & Technology |
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Online Access: | http://dx.doi.org/10.1111/ijfs.13396 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fijfs.13396 http://onlinelibrary.wiley.com/wol1/doi/10.1111/ijfs.13396/fullpdf |
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crwiley:10.1111/ijfs.13396 2024-06-23T07:45:03+00:00 The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells Chen, Qianru Guo, Lidong Du, Fen Chen, Tiejun Hou, Hu Li, Bafang National Natural Science Foundation of China China Scholarship Council 2017 http://dx.doi.org/10.1111/ijfs.13396 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fijfs.13396 http://onlinelibrary.wiley.com/wol1/doi/10.1111/ijfs.13396/fullpdf en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor International Journal of Food Science & Technology volume 52, issue 5, page 1283-1290 ISSN 0950-5423 1365-2621 journal-article 2017 crwiley https://doi.org/10.1111/ijfs.13396 2024-06-13T04:20:15Z Summary Gly‐Pro‐Ala‐Gly‐Pro‐His‐Gly‐Pro‐Pro‐Gly ( GPAGPHGPPG ), a chelating peptide derived from Alaska pollock skin, has been approved with outstanding ability to chelate calcium, zinc and iron ions. In this study, the stability of GPAGPHGPPG during in vitro g astrointestinal enzymatic digestion, the potential binding site between peptide and metal ions as well as its effects on mineral transport in Caco‐2 cells were investigated. Results showed that approximately 75% of GPAGPHGPPG remained intact at the end of the in vitro g astrointestinal enzymatic digestion. The formation of peptide‐metal complex was potentially related to histidine and cyclic structure in terms of dehydration. Moreover, GPAGPHGPPG revealed significant promotional effects on calcium (112.7%, P < 0.01), zinc (32.3%, P < 0.01) and iron (27.7%, P < 0.01) transport in Caco‐2 cell monolayer. In conclusion, GPAGPHGPPG could be developed as a potential functional ingredient to prevent mineral deficiency. Article in Journal/Newspaper alaska pollock Alaska Wiley Online Library International Journal of Food Science & Technology 52 5 1283 1290 |
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Open Polar |
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Wiley Online Library |
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crwiley |
language |
English |
description |
Summary Gly‐Pro‐Ala‐Gly‐Pro‐His‐Gly‐Pro‐Pro‐Gly ( GPAGPHGPPG ), a chelating peptide derived from Alaska pollock skin, has been approved with outstanding ability to chelate calcium, zinc and iron ions. In this study, the stability of GPAGPHGPPG during in vitro g astrointestinal enzymatic digestion, the potential binding site between peptide and metal ions as well as its effects on mineral transport in Caco‐2 cells were investigated. Results showed that approximately 75% of GPAGPHGPPG remained intact at the end of the in vitro g astrointestinal enzymatic digestion. The formation of peptide‐metal complex was potentially related to histidine and cyclic structure in terms of dehydration. Moreover, GPAGPHGPPG revealed significant promotional effects on calcium (112.7%, P < 0.01), zinc (32.3%, P < 0.01) and iron (27.7%, P < 0.01) transport in Caco‐2 cell monolayer. In conclusion, GPAGPHGPPG could be developed as a potential functional ingredient to prevent mineral deficiency. |
author2 |
National Natural Science Foundation of China China Scholarship Council |
format |
Article in Journal/Newspaper |
author |
Chen, Qianru Guo, Lidong Du, Fen Chen, Tiejun Hou, Hu Li, Bafang |
spellingShingle |
Chen, Qianru Guo, Lidong Du, Fen Chen, Tiejun Hou, Hu Li, Bafang The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells |
author_facet |
Chen, Qianru Guo, Lidong Du, Fen Chen, Tiejun Hou, Hu Li, Bafang |
author_sort |
Chen, Qianru |
title |
The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells |
title_short |
The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells |
title_full |
The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells |
title_fullStr |
The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells |
title_full_unstemmed |
The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells |
title_sort |
chelating peptide ( gpagphgppg) derived from alaska pollock skin enhances calcium, zinc and iron transport in caco‐2 cells |
publisher |
Wiley |
publishDate |
2017 |
url |
http://dx.doi.org/10.1111/ijfs.13396 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fijfs.13396 http://onlinelibrary.wiley.com/wol1/doi/10.1111/ijfs.13396/fullpdf |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
International Journal of Food Science & Technology volume 52, issue 5, page 1283-1290 ISSN 0950-5423 1365-2621 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1111/ijfs.13396 |
container_title |
International Journal of Food Science & Technology |
container_volume |
52 |
container_issue |
5 |
container_start_page |
1283 |
op_container_end_page |
1290 |
_version_ |
1802649530543374336 |