The chelating peptide ( GPAGPHGPPG) derived from Alaska pollock skin enhances calcium, zinc and iron transport in Caco‐2 cells

Summary Gly‐Pro‐Ala‐Gly‐Pro‐His‐Gly‐Pro‐Pro‐Gly ( GPAGPHGPPG ), a chelating peptide derived from Alaska pollock skin, has been approved with outstanding ability to chelate calcium, zinc and iron ions. In this study, the stability of GPAGPHGPPG during in vitro g astrointestinal enzymatic digestion, t...

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Bibliographic Details
Published in:International Journal of Food Science & Technology
Main Authors: Chen, Qianru, Guo, Lidong, Du, Fen, Chen, Tiejun, Hou, Hu, Li, Bafang
Other Authors: National Natural Science Foundation of China, China Scholarship Council
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2017
Subjects:
alaska pollock
Alaska
Online Access:http://dx.doi.org/10.1111/ijfs.13396
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fijfs.13396
http://onlinelibrary.wiley.com/wol1/doi/10.1111/ijfs.13396/fullpdf
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Summary:Summary Gly‐Pro‐Ala‐Gly‐Pro‐His‐Gly‐Pro‐Pro‐Gly ( GPAGPHGPPG ), a chelating peptide derived from Alaska pollock skin, has been approved with outstanding ability to chelate calcium, zinc and iron ions. In this study, the stability of GPAGPHGPPG during in vitro g astrointestinal enzymatic digestion, the potential binding site between peptide and metal ions as well as its effects on mineral transport in Caco‐2 cells were investigated. Results showed that approximately 75% of GPAGPHGPPG remained intact at the end of the in vitro g astrointestinal enzymatic digestion. The formation of peptide‐metal complex was potentially related to histidine and cyclic structure in terms of dehydration. Moreover, GPAGPHGPPG revealed significant promotional effects on calcium (112.7%, P < 0.01), zinc (32.3%, P < 0.01) and iron (27.7%, P < 0.01) transport in Caco‐2 cell monolayer. In conclusion, GPAGPHGPPG could be developed as a potential functional ingredient to prevent mineral deficiency.

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