Increase in tympanostomy tube placements despite pneumococcal vaccination, a population‐based study
Abstract Aim The aim was to estimate the impact of the 10‐valent pneumococcal vaccine ( PH iD‐ CV ) on tympanostomy tube placements ( TTP ) in children under five years of age in Iceland. Methods This population‐based observational cohort study followed 11 consecutive birth‐cohorts 2005–2015 from bi...
Published in: | Acta Paediatrica |
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Main Authors: | , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2019
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Subjects: | |
Online Access: | http://dx.doi.org/10.1111/apa.14724 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapa.14724 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apa.14724 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/apa.14724 |
Summary: | Abstract Aim The aim was to estimate the impact of the 10‐valent pneumococcal vaccine ( PH iD‐ CV ) on tympanostomy tube placements ( TTP ) in children under five years of age in Iceland. Methods This population‐based observational cohort study followed 11 consecutive birth‐cohorts 2005–2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. The risk of TTP was compared between birth‐cohorts adjusted for the number of previous otitis media diagnoses and antimicrobial prescriptions. A Cox regression model was applied and the hazard ratio ( HR ) of TTP was estimated between each birth‐cohort and the last vaccine non‐eligible birth‐cohort. The vaccine impact of PH iD‐ CV 10 on TTP was estimated as 1‐ HR ×100%. Results In total, 51 247 children were followed for 210 724 person‐years, of which 14 351 underwent 20 373 procedures. The estimated vaccine impact on TTP was −6% (95% CI −16% to 2.7%). Children in the vaccine‐eligible cohorts had fewer previous otitis media diagnoses and had been prescribed fewer antimicrobials prior to the procedure than children in the vaccine non‐eligible cohorts. Conclusion Despite high uptake of PH iD‐ CV 10, tympanostomy procedures increased in Iceland during the study period. Vaccine‐eligible children had milder disease prior to the procedure. The reason underlying these findings are speculative. |
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