Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations

Abstract Aim : To determine the frequency of thiopurine methyltransferase (TPMT) low‐activity alleles in the Greenlandic and Danish populations. Methods : 142 Greenlandic individuals and 200 Danish blood donors were screened for the TPMT G460A and A719G low‐activity alleles. Results: Thiopurine meth...

Full description

Bibliographic Details
Published in:Acta Paediatrica
Main Authors: TOFT, NINA, NYGAARD, ULRIKKA, GREGERS, JANNIE, SCHMIEGELOW, KJELD
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2006
Subjects:
greenlandic
Online Access:http://dx.doi.org/10.1080/08035250600743788
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1080%2F08035250600743788
https://onlinelibrary.wiley.com/doi/pdf/10.1080/08035250600743788
Description
Summary:Abstract Aim : To determine the frequency of thiopurine methyltransferase (TPMT) low‐activity alleles in the Greenlandic and Danish populations. Methods : 142 Greenlandic individuals and 200 Danish blood donors were screened for the TPMT G460A and A719G low‐activity alleles. Results: Thiopurine methyltransferase low‐activity alleles were significantly higher in the Greenlandic compared to the Danish population, being 8.1% (95% CI 4.9–11.3) and 3.5% (95% CI 1.7–5.3) (p<0.01), respectively. Except for one Danish patient with an A719G allele (TPMT*3C), all the aberrant alleles were compound G460A and A719G alleles (TPMT*3A). Conclusion : In the Danish population, the incidence of thiopurine methyltransferase low‐activity alleles was found to be similar to other Caucasian populations previously described. In contrast, the Greenlandic population showed a significantly higher frequency of thiopurine methyltransferase low‐activity alleles.

Similar Items