Wax Ester Rich Oil From The Marine Crustacean, Calanus finmarchicus, is a Bioavailable Source of EPA and DHA for Human Consumption

• Published in: Lipids
• Main Authors: Cook, Chad M., Larsen, Terje S., Derrig, Linda D., Kelly, Kathleen M., Tande, Kurt S.
• Other Authors: Calanus AS (Tromsø, Norway)
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2016
• Subjects: Calanus finmarchicus
• Online Access: http://dx.doi.org/10.1007/s11745-016-4189-y; http://link.springer.com/content/pdf/10.1007/s11745-016-4189-y.pdf; http://link.springer.com/article/10.1007/s11745-016-4189-y/fulltext.html; https://onlinelibrary.wiley.com/doi/full/10.1007/s11745-016-4189-y

Abstract Oil from the marine copepod, Calanus finmarchicus , which contains >86 % of fatty acids present as wax esters, is a novel source of n‐3 fatty acids for human consumption. In a randomized, two‐period crossover study, 18 healthy adults consumed 8 capsules providing 4 g of Calanus ® Oil supplying a total of 260 mg EPA and 156 mg DHA primarily as wax esters, or 1 capsule of Lovaza ® providing 465 mg EPA and 375 mg DHA as ethyl esters, each with an EPA‐ and DHA‐free breakfast. Plasma EPA and DHA were measured over a 72 h period ( t = 1, 2, 4, 6, 8, 10, 12, 24, 48, and 72 h). The positive incremental area under the curve over the 72 h test period (iAUC 0‐72 h ) for both EPA and DHA was significantly different from zero ( p < 0.0001) in both test conditions, with similar findings for the iAUC 0–24 h and iAUC 0–48 h , indicating the fatty acids were absorbed. There was no difference in the plasma iAUC 0–72 h for EPA + DHA, or DHA individually, in response to Calanus Oil vs the ethyl ester condition; however, the iAUC 0–48 h and iAUC 0–72 h for plasma EPA in response to Calanus Oil were both significantly increased relative to the ethyl ester condition (iAUC 0–48 h : 381 ± 31 vs 259 ± 39 μg*h/mL, p = 0.026; iAUC 0‐72 h : 514 ± 47 vs 313 ± 49 μg*h/mL, p = 0.009). These data demonstrate a novel wax ester rich marine oil is a suitable alternative source of EPA and DHA for human consumption.