Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization
Abstract The performance of poly(ϵ‐caprolactone) (PCL)‐based biomaterials is defined by spatial distributions of PCL's amorphous and crystalline domains. Unfortunately, directly visualizing their inner architectures has been challenging. This study demonstrates, the superior degradation selecti...
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crwiley:10.1002/mabi.201500175 2024-06-02T07:57:39+00:00 Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization Bauer, Adam J. P. Wu, Yitian Liu, Jianzhao Li, Bingbing 2015 http://dx.doi.org/10.1002/mabi.201500175 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmabi.201500175 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.201500175 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 http://onlinelibrary.wiley.com/termsAndConditions#vor Macromolecular Bioscience volume 15, issue 11, page 1554-1562 ISSN 1616-5187 1616-5195 journal-article 2015 crwiley https://doi.org/10.1002/mabi.201500175 2024-05-03T11:00:57Z Abstract The performance of poly(ϵ‐caprolactone) (PCL)‐based biomaterials is defined by spatial distributions of PCL's amorphous and crystalline domains. Unfortunately, directly visualizing their inner architectures has been challenging. This study demonstrates, the superior degradation selectivity of Candida antarctica lipase B (CALB) enzyme; when used at low concentrations, it preferentially breaks down the amorphous chains prior to the crystalline chains. Top‐down dissection using this enzyme is performed on several PCL‐based systems. Self‐assembled nanolamellae (e.g., thin films) or hierarchically nanostructured crystalline skeletons (e.g., fibers) are clearly captured. Thus, the spatial distribution of the amorphous compartments can be precisely mapped out, which otherwise cannot be achieved. Article in Journal/Newspaper Antarc* Antarctica Wiley Online Library Macromolecular Bioscience 15 11 1554 1562 |
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English |
description |
Abstract The performance of poly(ϵ‐caprolactone) (PCL)‐based biomaterials is defined by spatial distributions of PCL's amorphous and crystalline domains. Unfortunately, directly visualizing their inner architectures has been challenging. This study demonstrates, the superior degradation selectivity of Candida antarctica lipase B (CALB) enzyme; when used at low concentrations, it preferentially breaks down the amorphous chains prior to the crystalline chains. Top‐down dissection using this enzyme is performed on several PCL‐based systems. Self‐assembled nanolamellae (e.g., thin films) or hierarchically nanostructured crystalline skeletons (e.g., fibers) are clearly captured. Thus, the spatial distribution of the amorphous compartments can be precisely mapped out, which otherwise cannot be achieved. |
format |
Article in Journal/Newspaper |
author |
Bauer, Adam J. P. Wu, Yitian Liu, Jianzhao Li, Bingbing |
spellingShingle |
Bauer, Adam J. P. Wu, Yitian Liu, Jianzhao Li, Bingbing Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization |
author_facet |
Bauer, Adam J. P. Wu, Yitian Liu, Jianzhao Li, Bingbing |
author_sort |
Bauer, Adam J. P. |
title |
Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization |
title_short |
Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization |
title_full |
Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization |
title_fullStr |
Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization |
title_full_unstemmed |
Visualizing the Inner Architecture of Poly(ϵ‐caprolactone)‐Based Biomaterials and Its Impact on Performance Optimization |
title_sort |
visualizing the inner architecture of poly(ϵ‐caprolactone)‐based biomaterials and its impact on performance optimization |
publisher |
Wiley |
publishDate |
2015 |
url |
http://dx.doi.org/10.1002/mabi.201500175 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmabi.201500175 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.201500175 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Macromolecular Bioscience volume 15, issue 11, page 1554-1562 ISSN 1616-5187 1616-5195 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor http://doi.wiley.com/10.1002/tdm_license_1.1 http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/mabi.201500175 |
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Macromolecular Bioscience |
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15 |
container_issue |
11 |
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1554 |
op_container_end_page |
1562 |
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1800740833298743296 |