Determination of HBsAg subtypes in Western Siberian part of Russia
Abstract A set of monoclonal antibodies with specificity for hepatitis B surface antigen (HBsAg) was used for subtyping this antigen in sera from indigenous natives, blood donors, and drug users in Western Siberia with a modified commercial enzyme immunoassay kit for HBsAg detection. Three subtypes...
| Published in: | Journal of Medical Virology |
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| Main Authors: | , , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Wiley
2003
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1002/jmv.10468 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.10468 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.10468 |
| Summary: | Abstract A set of monoclonal antibodies with specificity for hepatitis B surface antigen (HBsAg) was used for subtyping this antigen in sera from indigenous natives, blood donors, and drug users in Western Siberia with a modified commercial enzyme immunoassay kit for HBsAg detection. Three subtypes of HBsAg in a ratio of 36 (78%) ayw2 :8 ayw3varB (18%):2 (4%) adw2 were found in 46 (100%) HBsAg‐positive sera of different aboriginal populations of Western Siberia: the Tundra Nenets, Northern Khanty, Southern Altaians, and Kazakhs. Four subtypes of HBsAg in a ratio of 81 (57%) ayw2 :58 (15 ayw3varA and 43 ayw3varB 44%):2 (1%) adw2 were detected in 141 (100%) samples of blood donors from ten cities of Western Siberia. Three subtypes of HBsAg in a ratio of 34 ayw3 :(both variants, 33 ayw3varA and 1 ayw3varB 97.1%):1 (2.9%) ayw2 were found in blood of 35 injection drug users in Novosibirsk. J. Med. Virol. 71:183–187, 2003. © 2003 Wiley‐Liss, Inc. |
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