Synthesis of N‐Acyl‐2‐amino‐2‐deoxy‐[1‐ 14 C]‐glucoses as precursors for the biosynthesis of novel N‐acylneuraminic acids
Abstract N‐Propanoyl‐, N‐butanoyl‐, N‐pentanoyl‐, N‐hexanoyl‐, N‐heptanoyl‐ and N‐crotonoyl‐[1‐ 14 C]‐D‐glucosamine were synthesized from [1‐ 14 C]‐D‐glucosamine and their respective carbonic acid anhydrides as precursors for the biosynthesis of the corresponding N‐acyl neuraminic acids. The N‐acyl‐...
| Published in: | Journal of Labelled Compounds and Radiopharmaceuticals |
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| Main Authors: | , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Wiley
1992
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1002/jlcr.2580310910 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjlcr.2580310910 https://onlinelibrary.wiley.com/doi/full/10.1002/jlcr.2580310910 |
| Summary: | Abstract N‐Propanoyl‐, N‐butanoyl‐, N‐pentanoyl‐, N‐hexanoyl‐, N‐heptanoyl‐ and N‐crotonoyl‐[1‐ 14 C]‐D‐glucosamine were synthesized from [1‐ 14 C]‐D‐glucosamine and their respective carbonic acid anhydrides as precursors for the biosynthesis of the corresponding N‐acyl neuraminic acids. The N‐acyl‐glucosamines are phosphorylated to their respective phosphate by N‐acetyl‐glucosamine kinase in a rat liver homogenate. These precursors may become valuable tools to investigate the biological role of the N‐acyl side chain of N‐acyl‐glucosamines and N‐acyl neuraminic acids which are components of glycoconjugates. |
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