Comparative study of hydrophobically modified gelatin‐based sealant with commercially available sealants

• Published in: Journal of Biomedical Materials Research Part A
• Main Authors: Mizuno, Yosuke, Watanabe, Shiharu, Katano, Mayumi, Yanagihara, Takahiro, Maki, Naoki, Sato, Yukio, Taguchi, Tetsushi
• Other Authors: Japan Society for the Promotion of Science
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2021
• Subjects: alaska pollock; Alaska
• Online Access: http://dx.doi.org/10.1002/jbm.a.37339; https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.a.37339; https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jbm.a.37339

Abstract Air leakage is one of the major complications related to pulmonary surgeries. To reduce this complication, we developed a decyl group (C10)‐modified Alaska pollock gelatin (ApGltn) (C10‐ApGltn) sealant and evaluated its practical performance against commercially available sealants, Beriplast® and DuraSeal®. C10‐ApGltn was synthesized by reductive amination of the amino groups in ApGltn with decanal. C10‐ApGltn was crosslinked with a poly(ethylene glycol)‐based crosslinker to form a tissue sealant. The crosslinking time of the C10‐ApGltn sealant was fast enough for curing on tissue and application as a spray system. Although the percent swelling of C10‐ApGltn and DuraSeal was significantly greater than Beriplast, C10‐ApGltn and DuraSeal exhibited excellent tissue sealing properties on pleura tissue under a long‐term moist condition. Additionally, C10‐ApGltn and DuraSeal did not cause severe inflammatory responses in a rat subcutaneous example. Therefore, C10‐ApGltn sealant had comparable tissue sealing properties to DuraSeal under a moist condition, indicating the potential of C10‐ApGltn sealant for pulmonary surgeries.