Promiscuous lipase catalyzed a new P–C bond formation: Green and efficient protocol for one‐pot synthesis of α‐aminophosphonates

• Published in: Heteroatom Chemistry
• Main Authors: Guezane‐Lakoud, Samia, Toffano, Martial, Aribi‐Zouioueche, Louisa
• Other Authors: Algerian Ministry of Higher Education and Scientific Research (DGRSDT, FNR)
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2017
• Subjects: Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1002/hc.21408; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhc.21408; https://onlinelibrary.wiley.com/doi/pdf/10.1002/hc.21408

Abstract α‐Aminophosphonates are valuable substructures with important biological and pharmacological properties. Lipase catalytic promiscuity is a new method in the organic synthesis for the preparation of α‐aminophosphonates via multicomponent reaction in one pot. This efficient, simple, and eco‐friendly method proceeds in the presence of immobilized Candida Antarctica lipase as catalyst under solvent‐free conditions at room temperature. The new α‐aminophosphonates are synthesized in high yields (up to 96%). Moreover, enzymatic‐catalyzed P–C bond formation through a Kabachnik‐Fields reaction was achieved for the first time.