Promiscuous lipase catalyzed a new P–C bond formation: Green and efficient protocol for one‐pot synthesis of α‐aminophosphonates

Abstract α‐Aminophosphonates are valuable substructures with important biological and pharmacological properties. Lipase catalytic promiscuity is a new method in the organic synthesis for the preparation of α‐aminophosphonates via multicomponent reaction in one pot. This efficient, simple, and eco‐f...

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Bibliographic Details
Published in:Heteroatom Chemistry
Main Authors: Guezane‐Lakoud, Samia, Toffano, Martial, Aribi‐Zouioueche, Louisa
Other Authors: Algerian Ministry of Higher Education and Scientific Research (DGRSDT, FNR)
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2017
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/hc.21408
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhc.21408
https://onlinelibrary.wiley.com/doi/pdf/10.1002/hc.21408
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Summary:Abstract α‐Aminophosphonates are valuable substructures with important biological and pharmacological properties. Lipase catalytic promiscuity is a new method in the organic synthesis for the preparation of α‐aminophosphonates via multicomponent reaction in one pot. This efficient, simple, and eco‐friendly method proceeds in the presence of immobilized Candida Antarctica lipase as catalyst under solvent‐free conditions at room temperature. The new α‐aminophosphonates are synthesized in high yields (up to 96%). Moreover, enzymatic‐catalyzed P–C bond formation through a Kabachnik‐Fields reaction was achieved for the first time.

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