Polycyclic Aromatic Hydrocarbons Alter the Hepatic Expression of Genes Involved in Sanderling ( Calidris alba) Pre‐migratory Fueling

Abstract Polycyclic aromatic hydrocarbons (PAHs) impaired pre‐migratory fueling in 49 orally dosed Sanderling ( Calidris alba ). In the present study, 8 genes related to fat deposition and PAH exposure were measured in liver subsamples from these same shorebirds. At the highest dose (1260 µg total P...

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Bibliographic Details
Published in:Environmental Toxicology and Chemistry
Main Authors: Bianchini, Kristin, Crump, Doug, Farhat, Amani, Morrissey, Christy A.
Other Authors: University of Saskatchewan, Natural Sciences and Engineering Research Council of Canada
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2021
Subjects:
Calidris alba
Sanderling
Online Access:http://dx.doi.org/10.1002/etc.5056
https://onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5056
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/etc.5056
https://setac.onlinelibrary.wiley.com/doi/pdf/10.1002/etc.5056
Description
Summary:Abstract Polycyclic aromatic hydrocarbons (PAHs) impaired pre‐migratory fueling in 49 orally dosed Sanderling ( Calidris alba ). In the present study, 8 genes related to fat deposition and PAH exposure were measured in liver subsamples from these same shorebirds. At the highest dose (1260 µg total PAH [tPAH]/kg body wt/day), PAH exposure decreased liver basic fatty acid binding protein 1 ( Lbfabp ) and hepatic lipase ( Lipc ) expression. The present study reveals candidate molecular‐level pathways for observed avian pre‐migratory refueling impairment. Environ Toxicol Chem 2021;40:1981–1989. © 2021 SETAC

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