Catalytic Synthesis of Functional Silicon‐Stereogenic Silanes through Candida antarctica Lipase B Catalyzed Remote Desymmetrization of Silicon‐Centered Diols
Abstract A series of silicon‐containing diols are synthesized and used in lipase‐catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon‐stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achi...
Published in: | European Journal of Organic Chemistry |
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Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2013
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/ejoc.201300932 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201300932 http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201300932/fullpdf |
Summary: | Abstract A series of silicon‐containing diols are synthesized and used in lipase‐catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon‐stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL‐B) (up to 90:10 er ). |
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