Catalytic Synthesis of Functional Silicon‐Stereogenic Silanes through Candida antarctica Lipase B Catalyzed Remote Desymmetrization of Silicon‐Centered Diols

Abstract A series of silicon‐containing diols are synthesized and used in lipase‐catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon‐stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achi...

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Bibliographic Details
Published in:European Journal of Organic Chemistry
Main Authors: Lu, Xing, Li, Li, Yang, Wei, Jiang, Kezhi, Yang, Ke‐Fang, Zheng, Zhan‐Jiang, Xu, Li‐Wen
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2013
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/ejoc.201300932
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201300932
http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201300932/fullpdf
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Summary:Abstract A series of silicon‐containing diols are synthesized and used in lipase‐catalyzed remote desymmetrization. This synthetic method is valuable in the construction of optically active silicon‐stereogenic organosilicon compounds. Good enantioselectivities of the remote desymmetrization was achieved with Candida antarctica lipase B (CAL‐B) (up to 90:10 er ).

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