Metal‐Free Directed ortho C–H Iodination: Synthesis of 2′‐Iodobiaryl‐2‐carbonitriles

Abstract Metal‐free directed ortho C–H iodination of biaryl‐2‐carbonitriles was developed. A series of 2′‐iodobiaryl‐2‐carbonitriles were synthesized from substituted biphenylcarbonitriles and naphthylbenzonitriles in reasonably good yields by using bis(pyridine)iodonium(I) tetrafluoroborate (IPy 2...

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Bibliographic Details
Published in:European Journal of Organic Chemistry
Main Authors: Sarkar, Satinath, Jana, Manoranjan, Narender, Tadigoppula
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2013
Subjects:
IPY
Online Access:http://dx.doi.org/10.1002/ejoc.201300584
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201300584
https://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201300584
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Summary:Abstract Metal‐free directed ortho C–H iodination of biaryl‐2‐carbonitriles was developed. A series of 2′‐iodobiaryl‐2‐carbonitriles were synthesized from substituted biphenylcarbonitriles and naphthylbenzonitriles in reasonably good yields by using bis(pyridine)iodonium(I) tetrafluoroborate (IPy 2 BF 4 , Barluenga's reagent) and HBF 4 · OEt 2 . The biaryl‐2‐carbonitriles are useful precursors for the synthesis of benzocyclic ketones.

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