Metal‐Free Directed ortho C–H Iodination: Synthesis of 2′‐Iodobiaryl‐2‐carbonitriles
Abstract Metal‐free directed ortho C–H iodination of biaryl‐2‐carbonitriles was developed. A series of 2′‐iodobiaryl‐2‐carbonitriles were synthesized from substituted biphenylcarbonitriles and naphthylbenzonitriles in reasonably good yields by using bis(pyridine)iodonium(I) tetrafluoroborate (IPy 2...
Published in: | European Journal of Organic Chemistry |
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Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2013
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/ejoc.201300584 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201300584 https://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201300584 |
Summary: | Abstract Metal‐free directed ortho C–H iodination of biaryl‐2‐carbonitriles was developed. A series of 2′‐iodobiaryl‐2‐carbonitriles were synthesized from substituted biphenylcarbonitriles and naphthylbenzonitriles in reasonably good yields by using bis(pyridine)iodonium(I) tetrafluoroborate (IPy 2 BF 4 , Barluenga's reagent) and HBF 4 · OEt 2 . The biaryl‐2‐carbonitriles are useful precursors for the synthesis of benzocyclic ketones. |
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