Effects of n‐3 PUFA on insulin resistance after an oral fat load
Abstract The aim of this study was to evaluate the effects of ω‐3 PUFA ( n ‐3 PUFA) on lipid profile and insulin resistance biomarkers. Patients were assigned to receive placebo or n ‐3 PUFA 1 g three times a day, during the meals, for 6 months. We evaluated: body mass index (BMI), body weight, fast...
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crwiley:10.1002/ejlt.201000504 2024-06-02T08:07:38+00:00 Effects of n‐3 PUFA on insulin resistance after an oral fat load Derosa, Giuseppe Cicero, Arrigo F.G. Fogari, Elena D'Angelo, Angela Bonaventura, Aldo Maffioli, Pamela 2011 http://dx.doi.org/10.1002/ejlt.201000504 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejlt.201000504 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.201000504 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.201000504 en eng Wiley http://onlinelibrary.wiley.com/termsAndConditions#vor European Journal of Lipid Science and Technology volume 113, issue 8, page 950-960 ISSN 1438-7697 1438-9312 journal-article 2011 crwiley https://doi.org/10.1002/ejlt.201000504 2024-05-03T10:42:37Z Abstract The aim of this study was to evaluate the effects of ω‐3 PUFA ( n ‐3 PUFA) on lipid profile and insulin resistance biomarkers. Patients were assigned to receive placebo or n ‐3 PUFA 1 g three times a day, during the meals, for 6 months. We evaluated: body mass index (BMI), body weight, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA‐IR), blood pressure, lipid profile, resistin (r), retinol binding protein‐4 (RBP‐4), adiponectin (ADN), visfatin, and vaspin. Furthermore patients underwent an oral fat load (OFL) and an euglycemic hyperinsulinemic clamp to evaluate M value, and total glucose requirement (TGR). Triglycerides value obtained with n ‐3 PUFA was lower, while HDL‐C, and ADN values were higher compared to placebo. After the OFL, and comparing the OFL performed at the baseline and at the end of the study, there was a decrease of triglycerides (Tg), resistin (r), and RBP‐4 values, and an increase of ADN value with n ‐3 PUFA, but not with placebo. We conclude that the treatment with n ‐3 PUFA resulted in a greater improvement of lipid profile and ADN compared to placebo in a baseline condition, and an improvement of all insulin resistance parameters after an OFL. Practical applications: The inverse association between dietary intake of n ‐3 PUFA and cardiovascular disease morbidity/mortality was primarily established following the observation that the Greenland Inuits had low mortality from coronary heart disease despite a fat‐rich diet. Our group has already shown that n ‐3 PUFA improved the lipid profile and the coagulation, fibrinolytic, and inflammatory parameters compared to placebo. We also observed that highly purified n ‐3 PUFA supplementation significantly reduced the blood pressure, pulse pressure, and basal heart rate in hypertriglyceridemic patients with normal‐high blood pressure. The current study showed that treatment with n ‐3 PUFA not only improved lipid profile in a baseline situation, but it also improved all ... Article in Journal/Newspaper Greenland inuits Wiley Online Library Greenland European Journal of Lipid Science and Technology 113 8 950 960 |
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Open Polar |
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Wiley Online Library |
op_collection_id |
crwiley |
language |
English |
description |
Abstract The aim of this study was to evaluate the effects of ω‐3 PUFA ( n ‐3 PUFA) on lipid profile and insulin resistance biomarkers. Patients were assigned to receive placebo or n ‐3 PUFA 1 g three times a day, during the meals, for 6 months. We evaluated: body mass index (BMI), body weight, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA‐IR), blood pressure, lipid profile, resistin (r), retinol binding protein‐4 (RBP‐4), adiponectin (ADN), visfatin, and vaspin. Furthermore patients underwent an oral fat load (OFL) and an euglycemic hyperinsulinemic clamp to evaluate M value, and total glucose requirement (TGR). Triglycerides value obtained with n ‐3 PUFA was lower, while HDL‐C, and ADN values were higher compared to placebo. After the OFL, and comparing the OFL performed at the baseline and at the end of the study, there was a decrease of triglycerides (Tg), resistin (r), and RBP‐4 values, and an increase of ADN value with n ‐3 PUFA, but not with placebo. We conclude that the treatment with n ‐3 PUFA resulted in a greater improvement of lipid profile and ADN compared to placebo in a baseline condition, and an improvement of all insulin resistance parameters after an OFL. Practical applications: The inverse association between dietary intake of n ‐3 PUFA and cardiovascular disease morbidity/mortality was primarily established following the observation that the Greenland Inuits had low mortality from coronary heart disease despite a fat‐rich diet. Our group has already shown that n ‐3 PUFA improved the lipid profile and the coagulation, fibrinolytic, and inflammatory parameters compared to placebo. We also observed that highly purified n ‐3 PUFA supplementation significantly reduced the blood pressure, pulse pressure, and basal heart rate in hypertriglyceridemic patients with normal‐high blood pressure. The current study showed that treatment with n ‐3 PUFA not only improved lipid profile in a baseline situation, but it also improved all ... |
format |
Article in Journal/Newspaper |
author |
Derosa, Giuseppe Cicero, Arrigo F.G. Fogari, Elena D'Angelo, Angela Bonaventura, Aldo Maffioli, Pamela |
spellingShingle |
Derosa, Giuseppe Cicero, Arrigo F.G. Fogari, Elena D'Angelo, Angela Bonaventura, Aldo Maffioli, Pamela Effects of n‐3 PUFA on insulin resistance after an oral fat load |
author_facet |
Derosa, Giuseppe Cicero, Arrigo F.G. Fogari, Elena D'Angelo, Angela Bonaventura, Aldo Maffioli, Pamela |
author_sort |
Derosa, Giuseppe |
title |
Effects of n‐3 PUFA on insulin resistance after an oral fat load |
title_short |
Effects of n‐3 PUFA on insulin resistance after an oral fat load |
title_full |
Effects of n‐3 PUFA on insulin resistance after an oral fat load |
title_fullStr |
Effects of n‐3 PUFA on insulin resistance after an oral fat load |
title_full_unstemmed |
Effects of n‐3 PUFA on insulin resistance after an oral fat load |
title_sort |
effects of n‐3 pufa on insulin resistance after an oral fat load |
publisher |
Wiley |
publishDate |
2011 |
url |
http://dx.doi.org/10.1002/ejlt.201000504 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejlt.201000504 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejlt.201000504 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejlt.201000504 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuits |
genre_facet |
Greenland inuits |
op_source |
European Journal of Lipid Science and Technology volume 113, issue 8, page 950-960 ISSN 1438-7697 1438-9312 |
op_rights |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
op_doi |
https://doi.org/10.1002/ejlt.201000504 |
container_title |
European Journal of Lipid Science and Technology |
container_volume |
113 |
container_issue |
8 |
container_start_page |
950 |
op_container_end_page |
960 |
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1800752734566088704 |