Effect of certain drugs on the incidence of seasickness

• Published in: Clinical Pharmacology & Therapeutics
• Main Authors: Trumbull, Richard, Chinn, Herman I., Maag, Clinton H., Milch, Lawrence J., Handford, S. Wing, Seibert, Richard, Sperling, Philip, Smith, Paul K.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 1960
• Subjects: North Atlantic
• Online Access: http://dx.doi.org/10.1002/cpt196013280; http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcpt196013280; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcpt196013280; https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/cpt196013280

Several drugs were tested, some of them for the first time, against seasickness in military personnel on transport ships on the North Atlantic ocean. All of the drugs were given three fimes a day. Of the new ones tested phenglutarmide, 2.5 mg., and cinnarazine, 7.5 mg., were significantly effective on a single trip. Somewhat less effective were atropine and orphenadrine. Ineffective new drugs were procyclidine, diethazine, cycrimine, caramiphen, pheniprazine, nialamide, phenelzine, benactyzine, and promazine. Cyclizine and meclizine, in doses of 50 mg. three times a day, were again found to be effective.