An Efficient Synthesis of 3‐Alkylpyridine Alkaloids Enables Their Biological Evaluation
Abstract 3‐Alkylpyridine alkaloids (3‐APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate require...
| Published in: | ChemMedChem |
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| Main Authors: | , , |
| Other Authors: | |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Wiley
2021
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1002/cmdc.202100134 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100134 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cmdc.202100134 |
| Summary: | Abstract 3‐Alkylpyridine alkaloids (3‐APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate requires the use of protecting groups and harsh conditions. In this work, we developed a simple and concise two‐step route to nine different natural and synthetic haliclocyclins. These compounds displayed modest antibiotic activity against several Gram‐positive bacterial strains. |
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