Effective enzymatic resolution of rac‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine

Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, I...

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Bibliographic Details
Published in:Chirality
Main Authors: D'Antona, Nicola, Mangiafico, Sebastiano, Nicolosi, Giovanni
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2002
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/chir.10072
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchir.10072
https://onlinelibrary.wiley.com/doi/pdf/10.1002/chir.10072
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Summary:Abstract Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, Inc.

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