Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones
Abstract Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An op...
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Online Access: | http://dx.doi.org/10.1002/chem.202102683 https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202102683 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.202102683 |
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crwiley:10.1002/chem.202102683 2024-06-02T07:58:47+00:00 Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. Vetenskapsrådet 2021 http://dx.doi.org/10.1002/chem.202102683 https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202102683 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.202102683 en eng Wiley http://creativecommons.org/licenses/by/4.0/ Chemistry – A European Journal volume 27, issue 63, page 15623-15627 ISSN 0947-6539 1521-3765 journal-article 2021 crwiley https://doi.org/10.1002/chem.202102683 2024-05-03T11:25:58Z Abstract Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios. Article in Journal/Newspaper antartic* Wiley Online Library Chemistry – A European Journal 27 63 15623 15627 |
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English |
description |
Abstract Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios. |
author2 |
Vetenskapsrådet |
format |
Article in Journal/Newspaper |
author |
Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. |
spellingShingle |
Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
author_facet |
Hilker, Simon Posevins, Daniels Unelius, C. Rikard Bäckvall, Jan‐E. |
author_sort |
Hilker, Simon |
title |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_short |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_full |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_fullStr |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_full_unstemmed |
Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones |
title_sort |
chemoenzymatic dynamic kinetic asymmetric transformations of β‐hydroxyketones |
publisher |
Wiley |
publishDate |
2021 |
url |
http://dx.doi.org/10.1002/chem.202102683 https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202102683 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.202102683 |
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antartic* |
genre_facet |
antartic* |
op_source |
Chemistry – A European Journal volume 27, issue 63, page 15623-15627 ISSN 0947-6539 1521-3765 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1002/chem.202102683 |
container_title |
Chemistry – A European Journal |
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27 |
container_issue |
63 |
container_start_page |
15623 |
op_container_end_page |
15627 |
_version_ |
1800742310183436288 |