Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones

Abstract Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An op...

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Bibliographic Details
Published in:Chemistry – A European Journal
Main Authors: Hilker, Simon, Posevins, Daniels, Unelius, C. Rikard, Bäckvall, Jan‐E.
Other Authors: Vetenskapsrådet
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2021
Subjects:
antartic*
Online Access:http://dx.doi.org/10.1002/chem.202102683
https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.202102683
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.202102683
Description
Summary:Abstract Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.

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