Chemoenzymatic Dynamic Kinetic Resolution of Primary Benzylic Amines using Pd 0 ‐CalB CLEA as a Biohybrid Catalyst

Abstract Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross‐linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an ef...

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Bibliographic Details
Published in:Chemistry – A European Journal
Main Authors: Gustafson, Karl P. J., Görbe, Tamás, de Gonzalo‐Calvo, Gonzalo, Yuan, Ning, Schreiber, Cynthia L., Shchukarev, Andrey, Tai, Cheuk‐Wai, Persson, Ingmar, Zou, Xiaodong, Bäckvall, Jan‐E.
Other Authors: Vetenskapsrådet
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2019
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/chem.201901418
https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201901418
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/chem.201901418
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Summary:Abstract Herein, we report on the use a biohybrid catalyst consisting of palladium nanoparticles immobilized on cross‐linked enzyme aggregates of lipase B of Candida antarctica (CalB CLEA) for the dynamic kinetic resolution (DKR) of benzylic amines. A set of amines were demonstrated to undergo an efficient DKR and the recyclability of the catalysts was studied. Extensive efforts to further elucidate the structure of the catalyst are presented.

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