A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols
Abstract A synthetic protocol making use of a well‐defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K 2 CO 3 ) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the deve...
| Published in: | Chemistry – A European Journal |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Wiley
2014
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1002/chem.201404096 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201404096 https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201404096 |
| Summary: | Abstract A synthetic protocol making use of a well‐defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K 2 CO 3 ) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec ‐alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantioenriched acetates in a one‐pot reaction, probing the versatility of complex 2 . |
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