Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris

Abstract Two new depsidones, himantormiones A and B ( 1 and 2 ) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds ( 3–9 ). The structures of two new compounds ( 1 and 2 ) were determined by means of spectroscopic analyses, includi...

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Bibliographic Details
Published in:Chemistry & Biodiversity
Main Authors: Hyung Koo, Man, Shin, Min‐Ji, Ju Kim, Min, Lee, Seulah, Eun So, Jae, Hee Kim, Ji, Hyuck Lee, Jun, Suh, Sung‐Suk, Joung Youn, Ui
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2022
Subjects:
Antarctic
The Antarctic
Antarc*
Online Access:http://dx.doi.org/10.1002/cbdv.202200374
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202200374
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cbdv.202200374
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Summary:Abstract Two new depsidones, himantormiones A and B ( 1 and 2 ) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds ( 3–9 ). The structures of two new compounds ( 1 and 2 ) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR‐MS. The isolated compounds were tested for antimicrobial and cytotoxic activities, where himantormione B ( 2 ) exhibited inhibitory effect against Staphylococcus aureus with the IC 50 value of 7.01±0.85 mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC 50 value of 1.11±0.85 μM, where that of the positive control, 5‐fluouracil, was 9.4±1.90 μM.

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