Bioactive Secondary Metabolites Isolated from the Antarctic Lichen Himantormia lugubris
Abstract Two new depsidones, himantormiones A and B ( 1 and 2 ) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds ( 3–9 ). The structures of two new compounds ( 1 and 2 ) were determined by means of spectroscopic analyses, includi...
Published in: | Chemistry & Biodiversity |
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Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2022
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/cbdv.202200374 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202200374 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cbdv.202200374 |
Summary: | Abstract Two new depsidones, himantormiones A and B ( 1 and 2 ) were isolated and identified from the Antarctic lichen, Himantormia lugubris (Parmeliaceae), with seven known compounds ( 3–9 ). The structures of two new compounds ( 1 and 2 ) were determined by means of spectroscopic analyses, including 1D and 2D NMR and HR‐MS. The isolated compounds were tested for antimicrobial and cytotoxic activities, where himantormione B ( 2 ) exhibited inhibitory effect against Staphylococcus aureus with the IC 50 value of 7.01±0.85 mM. Compound 2 also exhibited strong cytotoxic activity against HCT116 cells (colon cancer) with the EC 50 value of 1.11±0.85 μM, where that of the positive control, 5‐fluouracil, was 9.4±1.90 μM. |
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