Bioactive Tyrosine‐Derived Cytochalasins from Fungus Eutypella sp. D‐1

• Published in: Chemistry & Biodiversity
• Main Authors: Liu, Jing‐Tang, Hu, Bo, Gao, Yun, Zhang, Jian‐Peng, Jiao, Bing‐Hua, Lu, Xiao‐Ling, Liu, Xiao‐Yu
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2014
• Subjects: Arctic
• Online Access: http://dx.doi.org/10.1002/cbdv.201300218; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbdv.201300218; https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.201300218

Abstract Three new cytochalasins Z 24 , Z 25 , Z 26 ( 1 – 3 , resp.) and one known compound, scoparasin B ( 4 ), were isolated from the fungus Eutypella sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of 1 – 3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF‐7 cell line with IC 50 of 9.33 μ M .