Bioactive Tyrosine‐Derived Cytochalasins from Fungus Eutypella sp. D‐1
Abstract Three new cytochalasins Z 24 , Z 25 , Z 26 ( 1 – 3 , resp.) and one known compound, scoparasin B ( 4 ), were isolated from the fungus Eutypella sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of 1 – 3 were elucidated from spectroscopic data (NMR, MS). These com...
Published in: | Chemistry & Biodiversity |
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Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2014
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/cbdv.201300218 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbdv.201300218 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.201300218 |
Summary: | Abstract Three new cytochalasins Z 24 , Z 25 , Z 26 ( 1 – 3 , resp.) and one known compound, scoparasin B ( 4 ), were isolated from the fungus Eutypella sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of 1 – 3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF‐7 cell line with IC 50 of 9.33 μ M . |
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