Candida antarctica Lipase B (CAL‐B)‐Catalyzed Carbon‐Sulfur Bond Addition and Controllable Selectivity in Organic Media

Abstract A novel enzymatic, promiscuous protocol for Candida antarctica lipase B (CAL‐B)‐catalyzed carbon‐sulfur bond addition is described. Some control experiments have been designed to demonstrate the catalytic specificity of CAL‐B. Selectivity between anti‐Markovnikov addition and Markovnikov ad...

Full description

Bibliographic Details
Published in:Advanced Synthesis & Catalysis
Main Authors: Lou, Feng‐Wen, Liu, Bo‐Kai, Wu, Qi, Lv, De‐Shui, Lin, Xian‐Fu
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2008
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/adsc.200800207
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.200800207
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.200800207
Description
Summary:Abstract A novel enzymatic, promiscuous protocol for Candida antarctica lipase B (CAL‐B)‐catalyzed carbon‐sulfur bond addition is described. Some control experiments have been designed to demonstrate the catalytic specificity of CAL‐B. Selectivity between anti‐Markovnikov addition and Markovnikov addition was achieved in different organic media. A series of thioether‐containing ester functional groups was synthesized under the catalysis of CAL‐B at 50 °C. All the products were characterized by spectroscopic methods (IR, NMR, ESI‐MS).

Similar Items