Candida antarctica Lipase B (CAL‐B)‐Catalyzed Carbon‐Sulfur Bond Addition and Controllable Selectivity in Organic Media
Abstract A novel enzymatic, promiscuous protocol for Candida antarctica lipase B (CAL‐B)‐catalyzed carbon‐sulfur bond addition is described. Some control experiments have been designed to demonstrate the catalytic specificity of CAL‐B. Selectivity between anti‐Markovnikov addition and Markovnikov ad...
Published in: | Advanced Synthesis & Catalysis |
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Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2008
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Subjects: | |
Online Access: | http://dx.doi.org/10.1002/adsc.200800207 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.200800207 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.200800207 |
Summary: | Abstract A novel enzymatic, promiscuous protocol for Candida antarctica lipase B (CAL‐B)‐catalyzed carbon‐sulfur bond addition is described. Some control experiments have been designed to demonstrate the catalytic specificity of CAL‐B. Selectivity between anti‐Markovnikov addition and Markovnikov addition was achieved in different organic media. A series of thioether‐containing ester functional groups was synthesized under the catalysis of CAL‐B at 50 °C. All the products were characterized by spectroscopic methods (IR, NMR, ESI‐MS). |
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