Enzymatic Preparation of Novel Aminoalkylpyridines using Lipases in Organic Solvents
Abstract A wide range of novel, enantiomerically pure 4‐chloro(amino)pyridine derivatives has been synthesised through a chemoenzymatic approach, Candida antarctica lipase B (CAL‐B) and Pseudomonas cepacia lipase (PSL) being found to be excellent biocatalysts for the preparation of new and interesti...
Published in: | Advanced Synthesis & Catalysis |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2007
|
Subjects: | |
Online Access: | http://dx.doi.org/10.1002/adsc.200600634 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.200600634 https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.200600634 |
Summary: | Abstract A wide range of novel, enantiomerically pure 4‐chloro(amino)pyridine derivatives has been synthesised through a chemoenzymatic approach, Candida antarctica lipase B (CAL‐B) and Pseudomonas cepacia lipase (PSL) being found to be excellent biocatalysts for the preparation of new and interesting amines and amides in enantiomerically pure form through enzymatic aminolysis reactions. A study of the enzymatic reactivity of CAL‐B and PSL has been done in the resolution of a library of amine structures in an attempt to rationalise the experimental results obtained in their enzymatic kinetic resolution mediated by lipases. |
---|