Study of the Chemoselectivity in the Aminolysis Reaction of Methyl Acrylate Catalysed by Lipase B from Candida antarctica

Abstract The aminolysis reaction of methyl acrylate (MA) with N , N ‐dimethyl‐1,3‐propanediamine (DMAPA) in organic solvents has been optimised using lipase B from Candida antarctica (CAL‐B) as biocatalyst. A kinetic study about the influence of the reactant concentrations, organic solvent, temperat...

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Bibliographic Details
Published in:Advanced Synthesis & Catalysis
Main Authors: Torre, Oliver, Gotor‐Fernández, Vicente, Alfonso, Ignacio, García‐Alles, Luis Fernando, Gotor, Vicente
Format: Article in Journal/Newspaper
Language:English
Published: Wiley 2005
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1002/adsc.200505025
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadsc.200505025
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.200505025
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Summary:Abstract The aminolysis reaction of methyl acrylate (MA) with N , N ‐dimethyl‐1,3‐propanediamine (DMAPA) in organic solvents has been optimised using lipase B from Candida antarctica (CAL‐B) as biocatalyst. A kinetic study about the influence of the reactant concentrations, organic solvent, temperature and enzyme form has been developed focused on minimising the formation of the Michael addition products. The economic efficiency of this process has been finally investigated by reusing the enzyme in the best reaction conditions, thereby observing no significant loss of activity after three reaction cycles.

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