A Single-Center Experience of Antimicrobial Resistance Patterns in Pediatric Urinary Tract Infection

• Published in: Medical Principles and Practice
• Main Authors: Senel, Saliha, Karacan, Candemir, Erkek, Nilgun, Gol, Nese
• Format: Article in Journal/Newspaper
• Language: English
• Published: S. Karger AG 2010
• Subjects: General Medicine; sami
• Online Access: http://dx.doi.org/10.1159/000316373; https://www.karger.com/Article/Pdf/316373

<i>Objective:</i> To assess the prevalence of urinary tract pathogens and their resistance patterns against antimicrobial agents in a single center. <i>Patients and Methods:</i> In children <16 years of age admitted for urinary tract infection (UTI) to the Dr. Sami Ulus Teaching and Training Hospital from January 2004 to December 2008, positive urine cultures were reviewed. <i>Results:</i> A total of 3,485 positive urine cultures were identified, of which 2,379 (68%) were from females and 106 (32%) from males. Their mean age was 63.5 ± 40.7 months. <i>Escherichia coli</i> was the most common causative agent both in total and among different age groups. Ampicillin had the highest resistance rate from all the pathogens isolated (63.8%), followed by piperacillin (51.8%) and trimethoprim-sulfamethoxazole (TMP-SMX; 48.6%). Cephalotin also had a high resistance rate (32.7%). The least resistance was for imipenem, amikacin, netilmicin and ciprofloxacin (0.13, 1.7, 2.4 and 7.5%, respectively). None of the <i>Klebsiella</i> and <i>Pseudomonas</i> isolates were resistant to imipenem. None of the <i>Staphylococcus aureus</i> isolates were resistant to teicoplanin and vancomycin. Vancomycin-resistant <i>Enterococcus</i> spp. were isolated from two cultures. <i>Conclusion:</i><i>E. coli</i> was the most common causative agent of UTI in children. Ampicillin, TMP-SMX or cephalothin and piperacillin had the highest resistance rates against urinary tract pathogens in our center.