Pathology of Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Canada Geese (Branta canadensis)

Susceptibility of Canada geese ( Branta canadensis) to highly pathogenic avian influenza (HPAI) virus (H5N1) infection was studied by inoculating 10 naïve (antibody-negative) animals (5 adults and 5 juveniles) with A/chicken/Vietnam/14/05 (H5N1) virus. In the adults, 1 of 5 became infected, and 4 of...

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Bibliographic Details
Published in:Veterinary Pathology
Main Authors: Neufeld, J. L., Embury-Hyatt, C., Berhane, Y., Manning, L., Ganske, S., Pasick, J.
Format: Article in Journal/Newspaper
Language:English
Published: SAGE Publications 2009
Subjects:
General Veterinary
Canada
Branta canadensis
Online Access:http://dx.doi.org/10.1354/vp.08-vp-0168-e-fl
http://journals.sagepub.com/doi/pdf/10.1354/vp.08-VP-0168-E-FL
http://journals.sagepub.com/doi/full-xml/10.1354/vp.08-VP-0168-E-FL
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Summary:Susceptibility of Canada geese ( Branta canadensis) to highly pathogenic avian influenza (HPAI) virus (H5N1) infection was studied by inoculating 10 naïve (antibody-negative) animals (5 adults and 5 juveniles) with A/chicken/Vietnam/14/05 (H5N1) virus. In the adults, 1 of 5 became infected, and 4 of 5 remained normal; in the juvenile group, 5 of 5 became infected. The pathology observed in the affected animals was similar to that reported in natural occurrences. Peripheral and parasympathetic nervous systems were examined and found infected, as well as cerebrospinal fluid-contacting neurons. In some locations with significant virus infection in cells, the expected inflammatory reaction was absent or very mild. Immunohistochemistry was used to locate influenza A virus nucleoprotein in brain, spinal cord, respiratory and digestive systems, pancreas, heart, and peripheral and parasympathetic nervous systems. Further studies are needed to explain age-related differences in susceptibility.

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