Kolgaosides A and B, Two New Triterpene Glycosides from the Arctic Deep Water Sea Cucumber Kolga hyalina (Elasipodida: Elpidiidae)

Two novel triterpene holostane nonsulfated pentaosides, kolgaosides A (1) and B (2), and one known, holothurinoside B (3), were isolated from the Arctic sea cucumber Kolga hyalina, the second representative of the family Elpidiidae, order Elasipodida, from which triterpene glycosides have been obtai...

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Bibliographic Details
Published in:Natural Product Communications
Main Authors: Silchenko, Alexandra S., Kalinovsky, Anatoly I., Avilov, Sergey A., Andryjashchenko, Pelageya V., Fedorov, Sergey N., Dmitrenok, Pavel S., Yurchenko, Ekaterina A., Kalinin, Vladimir I., Rogacheva, Antonina V., Gebruk, Andrey V.
Format: Article in Journal/Newspaper
Language:English
Published: SAGE Publications 2014
Subjects:
Complementary and alternative medicine
Plant Science
Drug Discovery
Pharmacology
General Medicine
Antarctic
Arctic
The Antarctic
Antarc*
Online Access:http://dx.doi.org/10.1177/1934578x1400900910
http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900910
Description
Summary:Two novel triterpene holostane nonsulfated pentaosides, kolgaosides A (1) and B (2), and one known, holothurinoside B (3), were isolated from the Arctic sea cucumber Kolga hyalina, the second representative of the family Elpidiidae, order Elasipodida, from which triterpene glycosides have been obtained. The structures of 1 and 2 were elucidated using 1 H and 13 C NMR and 2D NMR procedures (HSQC, HMBC, COSY, ROESY, TOCSY) and HRESI mass-spectrometry. Kolgaosides A (1) and B (2) demonstrate low cytotoxic activity against the cells of the ascite form of mouse Ehrlich carcinoma and moderate hemolytic activity against mouse erythrocytes, despite the presence of hydroxy groups in the side chains of the aglycones. The glycosides of K. hyalina are similar to those of the Antarctic sea cucumber Rhipidothuria racowitzai Hèrouard, 1901 (= Achlionice violaescupidata) (Elasipodida: Elpidiidae); this may have chemotaxonomic significance.

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