De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles

Arvicolines are susceptible to the development of fatty liver during short-term fasting. We examined the potential role of de novo lipogenesis (DNL) (i) in the development of fasting-induced fatty liver and (ii) during a population cycle by measuring the mRNA expression of acetyl-CoA carboxylase-1 (...

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Bibliographic Details
Published in:Experimental Biology and Medicine
Main Authors: Nieminen, Petteri, Rouvinen-Watt, Kirsti, Harris, Lora, Huitu, Otso, Henttonen, Heikki, Mustonen, Anne-Mari
Format: Article in Journal/Newspaper
Language:English
Published: SAGE Publications 2016
Subjects:
General Biochemistry, Genetics and Molecular Biology
Microtus arvalis
Online Access:http://dx.doi.org/10.1177/1535370216633312
http://journals.sagepub.com/doi/pdf/10.1177/1535370216633312
http://journals.sagepub.com/doi/full-xml/10.1177/1535370216633312
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Summary:Arvicolines are susceptible to the development of fatty liver during short-term fasting. We examined the potential role of de novo lipogenesis (DNL) (i) in the development of fasting-induced fatty liver and (ii) during a population cycle by measuring the mRNA expression of acetyl-CoA carboxylase-1 (ACC1) and fatty acid synthase (FAS). Laboratory voles ( Microtus oeconomus and Microtus arvalis) were fed or fasted for 12 or 18 h and their liver mRNA levels were determined. Both species showed decreased mRNA expression of ACC1 and FAS during fasting. This suggests that DNL does not participate in the development of fatty liver in voles, different from human non-alcoholic fatty liver disease. In wild bank voles ( Myodes glareolus), the mRNA levels of the genes of interest were higher during the population decline compared to the increase phase. In conclusion, DNL was suppressed during acute fasting but upregulated during a long-term population decline—a period of purported scarcity of high-quality food.

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