A follow-up study of Nordic multiple sclerosis candidate gene regions

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers dis...

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Bibliographic Details
Published in:Multiple Sclerosis Journal
Main Authors: Datta, P., Harbo, H.F., Ryder, L.P., Akesson, E., Benedikz, J., Celius, E.G., Andersen, O., Myhr, K.-M., Sandberg-Wollheim, M., Hillert, J., Svejgaard, A., Sorensen, P.S., Spurkland, A., Oturai, A.
Format: Article in Journal/Newspaper
Language:English
Published: SAGE Publications 2007
Subjects:
Norway
Iceland
Online Access:http://dx.doi.org/10.1177/1352458506071790
https://journals.sagepub.com/doi/pdf/10.1177/1352458506071790
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Summary:In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population. Multiple Sclerosis 2007; 13: 584-589. http://msj.sagepub.com

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