S-100 Immunoreactivity in Melanomas of Two Marsupials, a Bird, and a Reptile
S-100 proteins are abundant in melanocytes of the skin; thus, S-100 immunoreactivity has been used as a diagnostic criterion for melanoma in humans and other placental mammals. We tested cutaneous melanomas of two marsupials, a bird, and a snake for S-100 immunoreactivity, using a polyclonal rabbit...
| Published in: | Veterinary Pathology |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
SAGE Publications
1997
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1177/030098589703400610 https://journals.sagepub.com/doi/pdf/10.1177/030098589703400610 |
| Summary: | S-100 proteins are abundant in melanocytes of the skin; thus, S-100 immunoreactivity has been used as a diagnostic criterion for melanoma in humans and other placental mammals. We tested cutaneous melanomas of two marsupials, a bird, and a snake for S-100 immunoreactivity, using a polyclonal rabbit antibovine S-100 antibody. The tumor from a Tasmanian Pademelon ( Thylogale billardierii) was composed of large epithelioid cells, most of which had S-100–positive cytoplasm. In general, there were only scattered individual spindle-shaped S-100–positive cells or groups of cells in the primary mass from a Spotted-tailed Quoll ( Dasyurus maculates); S-100 staining was primarily nuclear. Cells comprising the melanomas of the Australian Cormorant ( Phalacrocorax carbo) and the Death Adder ( Acanthophis antarcticus) were S-100–negative, although peripheral nerve bundles in both were S-100–positive. |
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