Inhibitory effects of Atlantic cod ( Gadus morhua) peptides on RANKL-induced osteoclastogenesis in vitro and osteoporosis in ovariectomized mice

Gadus morhua inhibited RANKL-induced osteoclast formation by inhibiting the activation of MAPK and NF-κB pathways and reduced the bone loss caused by estrogen deficiency in OVX-mice, showing potential anti-osteoporosis activity.

Bibliographic Details
Published in:Food & Function
Main Authors: Yang, Meilian, Wu, Di, Cheng, Shuzhen, Dong, Yu, Wu, Chao, Wang, Zhenyu, Du, Ming
Other Authors: National Natural Science Foundation of China
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2022
Subjects:
atlantic cod
Gadus morhua
Online Access:http://dx.doi.org/10.1039/d1fo03696c
http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO03696C
Description
Summary:Gadus morhua inhibited RANKL-induced osteoclast formation by inhibiting the activation of MAPK and NF-κB pathways and reduced the bone loss caused by estrogen deficiency in OVX-mice, showing potential anti-osteoporosis activity.

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