The influence of a type III antifreeze protein and its mutants on methane hydrate adsorption–inhibition: a molecular dynamics simulation study

Antifreeze proteins inhibit hydrate growth by hydrophobic interactions in cooperation with hydrogen bonds. Mutation of three polar amino acids (Asn14, Thr18, and Gln44) elucidates the molecular mechanism of AFP III antifreeze activity.

Bibliographic Details
Published in:Physical Chemistry Chemical Physics
Main Authors: Maddah, Mitra, Maddah, Mina, Peyvandi, Kiana
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2019
Subjects:
Methane hydrate
Online Access:http://dx.doi.org/10.1039/c9cp03833g
http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP03833G
Description
Summary:Antifreeze proteins inhibit hydrate growth by hydrophobic interactions in cooperation with hydrogen bonds. Mutation of three polar amino acids (Asn14, Thr18, and Gln44) elucidates the molecular mechanism of AFP III antifreeze activity.

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