Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate

Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate.

Bibliographic Details
Published in:Catalysis Science & Technology
Main Authors: Shen, Jiang-Wei, Qi, Jia-Mei, Zhang, Xiao-Jian, Liu, Zhi-Qiang, Zheng, Yu-Guo
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2018
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1039/c8cy01340c
http://pubs.rsc.org/en/content/articlepdf/2018/CY/C8CY01340C
id crroyalschem:10.1039/c8cy01340c
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spelling crroyalschem:10.1039/c8cy01340c 2024-05-19T07:32:01+00:00 Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate Shen, Jiang-Wei Qi, Jia-Mei Zhang, Xiao-Jian Liu, Zhi-Qiang Zheng, Yu-Guo 2018 http://dx.doi.org/10.1039/c8cy01340c http://pubs.rsc.org/en/content/articlepdf/2018/CY/C8CY01340C en eng Royal Society of Chemistry (RSC) http://rsc.li/journals-terms-of-use Catalysis Science & Technology volume 8, issue 18, page 4718-4725 ISSN 2044-4753 2044-4761 journal-article 2018 crroyalschem https://doi.org/10.1039/c8cy01340c 2024-04-25T08:06:27Z Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate. Article in Journal/Newspaper Antarc* Antarctica Royal Society of Chemistry Catalysis Science & Technology 8 18 4718 4725
institution Open Polar
collection Royal Society of Chemistry
op_collection_id crroyalschem
language English
description Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate.
format Article in Journal/Newspaper
author Shen, Jiang-Wei
Qi, Jia-Mei
Zhang, Xiao-Jian
Liu, Zhi-Qiang
Zheng, Yu-Guo
spellingShingle Shen, Jiang-Wei
Qi, Jia-Mei
Zhang, Xiao-Jian
Liu, Zhi-Qiang
Zheng, Yu-Guo
Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
author_facet Shen, Jiang-Wei
Qi, Jia-Mei
Zhang, Xiao-Jian
Liu, Zhi-Qiang
Zheng, Yu-Guo
author_sort Shen, Jiang-Wei
title Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
title_short Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
title_full Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
title_fullStr Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
title_full_unstemmed Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
title_sort significantly increased catalytic activity of candida antarctica lipase b for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate
publisher Royal Society of Chemistry (RSC)
publishDate 2018
url http://dx.doi.org/10.1039/c8cy01340c
http://pubs.rsc.org/en/content/articlepdf/2018/CY/C8CY01340C
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_source Catalysis Science & Technology
volume 8, issue 18, page 4718-4725
ISSN 2044-4753 2044-4761
op_rights http://rsc.li/journals-terms-of-use
op_doi https://doi.org/10.1039/c8cy01340c
container_title Catalysis Science & Technology
container_volume 8
container_issue 18
container_start_page 4718
op_container_end_page 4725
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