Significantly increased catalytic activity of Candida antarctica lipase B for the resolution of cis-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate

Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate.

Bibliographic Details
Published in:Catalysis Science & Technology
Main Authors: Shen, Jiang-Wei, Qi, Jia-Mei, Zhang, Xiao-Jian, Liu, Zhi-Qiang, Zheng, Yu-Guo
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2018
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1039/c8cy01340c
http://pubs.rsc.org/en/content/articlepdf/2018/CY/C8CY01340C
Description
Summary:Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate.

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