Efficient production of (R)-3-TBDMSO glutaric acid methyl monoester by manipulating the substrate pocket of Pseudozyma antarctica lipase B

Efficient production of optically pure ( R )-3-substituted glutaric acid methyl monoesters, the multifunctional chiral building blocks used in the pharmaceutical industry, by manipulating the substrate pocket of Pseudozyma antarctica lipase B.

Bibliographic Details
Published in:RSC Advances
Main Authors: Wu, Jing, Wang, Hongjiang, Yang, Bin, Song, Wei, Liang, Chenchen, Liu, Liming
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2017
Subjects:
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1039/c7ra06016e
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA06016E
Description
Summary:Efficient production of optically pure ( R )-3-substituted glutaric acid methyl monoesters, the multifunctional chiral building blocks used in the pharmaceutical industry, by manipulating the substrate pocket of Pseudozyma antarctica lipase B.

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