Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

Bibliographic Details
Published in:Chemical Communications
Main Authors: Sreenilayam, Gopeekrishnan, Fasan, Rudi
Other Authors: National Institutes of Health, Division of Chemistry
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2015
Subjects:
Sperm whale
Online Access:http://dx.doi.org/10.1039/c4cc08753d
http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC08753D
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spelling crroyalschem:10.1039/c4cc08753d 2024-06-23T07:56:58+00:00 Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates Sreenilayam, Gopeekrishnan Fasan, Rudi National Institutes of Health Division of Chemistry 2015 http://dx.doi.org/10.1039/c4cc08753d http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC08753D en eng Royal Society of Chemistry (RSC) Chemical Communications volume 51, issue 8, page 1532-1534 ISSN 1359-7345 1364-548X journal-article 2015 crroyalschem https://doi.org/10.1039/c4cc08753d 2024-06-10T04:16:58Z Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope. Article in Journal/Newspaper Sperm whale Royal Society of Chemistry Chemical Communications 51 8 1532 1534
institution Open Polar
collection Royal Society of Chemistry
op_collection_id crroyalschem
language English
description Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.
author2 National Institutes of Health
Division of Chemistry
format Article in Journal/Newspaper
author Sreenilayam, Gopeekrishnan
Fasan, Rudi
spellingShingle Sreenilayam, Gopeekrishnan
Fasan, Rudi
Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
author_facet Sreenilayam, Gopeekrishnan
Fasan, Rudi
author_sort Sreenilayam, Gopeekrishnan
title Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
title_short Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
title_full Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
title_fullStr Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
title_full_unstemmed Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
title_sort myoglobin-catalyzed intermolecular carbene n–h insertion with arylamine substrates
publisher Royal Society of Chemistry (RSC)
publishDate 2015
url http://dx.doi.org/10.1039/c4cc08753d
http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC08753D
genre Sperm whale
genre_facet Sperm whale
op_source Chemical Communications
volume 51, issue 8, page 1532-1534
ISSN 1359-7345 1364-548X
op_doi https://doi.org/10.1039/c4cc08753d
container_title Chemical Communications
container_volume 51
container_issue 8
container_start_page 1532
op_container_end_page 1534
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