Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

Bibliographic Details
Published in:Chemical Communications
Main Authors: Sreenilayam, Gopeekrishnan, Fasan, Rudi
Other Authors: National Institutes of Health, Division of Chemistry
Format: Article in Journal/Newspaper
Language:English
Published: Royal Society of Chemistry (RSC) 2015
Subjects:
Sperm whale
Online Access:http://dx.doi.org/10.1039/c4cc08753d
http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC08753D
Description
Summary:Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

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