Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.
Published in: | Chemical Communications |
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Main Authors: | , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Royal Society of Chemistry (RSC)
2015
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Subjects: | |
Online Access: | http://dx.doi.org/10.1039/c4cc08753d http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC08753D |
Summary: | Engineered variants of sperm whale myoglobin efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope. |
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