Addressing Exaggeration of Effects from Single RCTs
Abstract Randomised controlled trials are often presented as the gold standard for testing new medical treatments. In the early stages of research, however, reports from single trials are likely to show exaggerated effect estimates. Erik van Zwet, Simon Schwab and Sander Greenland explain why – and...
| Published in: | Significance |
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| Main Authors: | , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Oxford University Press (OUP)
2021
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1111/1740-9713.01587 https://onlinelibrary.wiley.com/doi/pdf/10.1111/1740-9713.01587 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/1740-9713.01587 https://academic.oup.com/jrssig/article-pdf/18/6/16/49188538/sign_18_6_16.pdf |
| Summary: | Abstract Randomised controlled trials are often presented as the gold standard for testing new medical treatments. In the early stages of research, however, reports from single trials are likely to show exaggerated effect estimates. Erik van Zwet, Simon Schwab and Sander Greenland explain why – and propose a remedy |
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