Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People
ABSTRACT Background The relationship between dietary n-3 PUFAs and the prevention of cardiometabolic diseases, including type 2 diabetes, is unresolved. Examination of the association between n-3 PUFAs and chronic low-grade inflammation in a population where many individuals have had an extremely hi...
Published in: | The Journal of Nutrition |
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2021
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Online Access: | http://dx.doi.org/10.1093/jn/nxab412 https://academic.oup.com/jn/advance-article-pdf/doi/10.1093/jn/nxab412/42249206/nxab412.pdf https://academic.oup.com/jn/article-pdf/152/3/844/42686502/nxab412.pdf |
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croxfordunivpr:10.1093/jn/nxab412 2023-05-15T18:46:01+02:00 Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People Boyer, Bert B Hopkins, Scarlett E Wiener, Howard W Purnell, Jonathan Q O'Brien, Diane M Zhang, Cindy X Aslan, Joseph E Aliwarga, Theresa Pomeroy, Jeremy J Thummel, Kenneth E Tiwari, Hemant K NIH Oregon National Primate Research Center 2021 http://dx.doi.org/10.1093/jn/nxab412 https://academic.oup.com/jn/advance-article-pdf/doi/10.1093/jn/nxab412/42249206/nxab412.pdf https://academic.oup.com/jn/article-pdf/152/3/844/42686502/nxab412.pdf en eng Oxford University Press (OUP) https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model The Journal of Nutrition volume 152, issue 3, page 844-855 ISSN 0022-3166 1541-6100 Nutrition and Dietetics Medicine (miscellaneous) journal-article 2021 croxfordunivpr https://doi.org/10.1093/jn/nxab412 2022-12-30T10:35:08Z ABSTRACT Background The relationship between dietary n-3 PUFAs and the prevention of cardiometabolic diseases, including type 2 diabetes, is unresolved. Examination of the association between n-3 PUFAs and chronic low-grade inflammation in a population where many individuals have had an extremely high intake of marine mammals and fish throughout their lifespan may provide important clues regarding the impact of n-3 PUFAs on health. Objectives The aim of this study was to explore associations between concentrations of n-3 PUFAs resulting from habitual intake of natural food sources high in fish and marine mammals with immune biomarkers of metabolic inflammation and parameters of glucose regulation. Methods A total of 569 Yup'ik Alaska Native adults (18–87 years old) were enrolled in this cross-sectional study between December 2016 and November 2019. The RBC nitrogen isotope ratio (NIR; 15N/14N) was used as a validated measure of n-3 PUFA intake to select 165 participant samples from the first and fourth quartiles of n-3 PUFA intakes. Outcomes included 38 pro- and anti-inflammatory cytokines and 8 measures of glucose homeostasis associated with type 2 diabetes risks. These outcomes were evaluated for their associations with direct measurements of EPA, DHA, and arachidonic acid in RBCs. Analysis Linear regression was used to detect significant relationships with cytokines and n-3 PUFAs, adiposity, and glucose-related variables. Results The DHA concentration in RBC membranes was inversely associated with IL-6 (β = –0.0066; P < 0.001); EPA was inversely associated with TNFα (β = –0.4925; P < 0.001); and the NIR was inversely associated with Monocyte chemoattractant protein-1 (MCP-1) (β = –0.8345; P < 0.001) and IL-10 (β = –1.2868; P < 0.001). Conclusions Habitual intake of marine mammals and fish rich in n-3 PUFAs in this study population of Yup'ik Alaska Native adults is associated with reduced systemic inflammation, which may contribute to the low prevalence of diseases in which ... Article in Journal/Newspaper Yup'ik Alaska Oxford University Press (via Crossref) The Journal of Nutrition |
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Open Polar |
collection |
Oxford University Press (via Crossref) |
op_collection_id |
croxfordunivpr |
language |
English |
topic |
Nutrition and Dietetics Medicine (miscellaneous) |
spellingShingle |
Nutrition and Dietetics Medicine (miscellaneous) Boyer, Bert B Hopkins, Scarlett E Wiener, Howard W Purnell, Jonathan Q O'Brien, Diane M Zhang, Cindy X Aslan, Joseph E Aliwarga, Theresa Pomeroy, Jeremy J Thummel, Kenneth E Tiwari, Hemant K Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People |
topic_facet |
Nutrition and Dietetics Medicine (miscellaneous) |
description |
ABSTRACT Background The relationship between dietary n-3 PUFAs and the prevention of cardiometabolic diseases, including type 2 diabetes, is unresolved. Examination of the association between n-3 PUFAs and chronic low-grade inflammation in a population where many individuals have had an extremely high intake of marine mammals and fish throughout their lifespan may provide important clues regarding the impact of n-3 PUFAs on health. Objectives The aim of this study was to explore associations between concentrations of n-3 PUFAs resulting from habitual intake of natural food sources high in fish and marine mammals with immune biomarkers of metabolic inflammation and parameters of glucose regulation. Methods A total of 569 Yup'ik Alaska Native adults (18–87 years old) were enrolled in this cross-sectional study between December 2016 and November 2019. The RBC nitrogen isotope ratio (NIR; 15N/14N) was used as a validated measure of n-3 PUFA intake to select 165 participant samples from the first and fourth quartiles of n-3 PUFA intakes. Outcomes included 38 pro- and anti-inflammatory cytokines and 8 measures of glucose homeostasis associated with type 2 diabetes risks. These outcomes were evaluated for their associations with direct measurements of EPA, DHA, and arachidonic acid in RBCs. Analysis Linear regression was used to detect significant relationships with cytokines and n-3 PUFAs, adiposity, and glucose-related variables. Results The DHA concentration in RBC membranes was inversely associated with IL-6 (β = –0.0066; P < 0.001); EPA was inversely associated with TNFα (β = –0.4925; P < 0.001); and the NIR was inversely associated with Monocyte chemoattractant protein-1 (MCP-1) (β = –0.8345; P < 0.001) and IL-10 (β = –1.2868; P < 0.001). Conclusions Habitual intake of marine mammals and fish rich in n-3 PUFAs in this study population of Yup'ik Alaska Native adults is associated with reduced systemic inflammation, which may contribute to the low prevalence of diseases in which ... |
author2 |
NIH Oregon National Primate Research Center |
format |
Article in Journal/Newspaper |
author |
Boyer, Bert B Hopkins, Scarlett E Wiener, Howard W Purnell, Jonathan Q O'Brien, Diane M Zhang, Cindy X Aslan, Joseph E Aliwarga, Theresa Pomeroy, Jeremy J Thummel, Kenneth E Tiwari, Hemant K |
author_facet |
Boyer, Bert B Hopkins, Scarlett E Wiener, Howard W Purnell, Jonathan Q O'Brien, Diane M Zhang, Cindy X Aslan, Joseph E Aliwarga, Theresa Pomeroy, Jeremy J Thummel, Kenneth E Tiwari, Hemant K |
author_sort |
Boyer, Bert B |
title |
Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People |
title_short |
Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People |
title_full |
Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People |
title_fullStr |
Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People |
title_full_unstemmed |
Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People |
title_sort |
habitual intake of marine-derived n-3 pufas is inversely associated with a cardiometabolic inflammatory profile in yup'ik alaska native people |
publisher |
Oxford University Press (OUP) |
publishDate |
2021 |
url |
http://dx.doi.org/10.1093/jn/nxab412 https://academic.oup.com/jn/advance-article-pdf/doi/10.1093/jn/nxab412/42249206/nxab412.pdf https://academic.oup.com/jn/article-pdf/152/3/844/42686502/nxab412.pdf |
genre |
Yup'ik Alaska |
genre_facet |
Yup'ik Alaska |
op_source |
The Journal of Nutrition volume 152, issue 3, page 844-855 ISSN 0022-3166 1541-6100 |
op_rights |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
op_doi |
https://doi.org/10.1093/jn/nxab412 |
container_title |
The Journal of Nutrition |
_version_ |
1766237255075102720 |