O-198 Obstetric and neonatal outcomes after natural frozen embryo transfer; results from a follow-up study of the Antarctica-2 RCT

• Published in: Human Reproduction
• Main Authors: Zaat, T, De Bruin, J P, Goddijn, M, Van Wely, M, Mol, F
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oxford University Press (OUP) 2023
• Subjects: Obstetrics and Gynecology; Rehabilitation; Reproductive Medicine; Antarc*; Antarctica
• Online Access: http://dx.doi.org/10.1093/humrep/dead093.239; https://academic.oup.com/humrep/article-pdf/38/Supplement_1/dead093.239/50787165/dead093.239.pdf

Abstract Study question Do obstetric and neonatal outcomes of women who conceived through home-based monitoring of the ovulation in natural cycle frozen embryo transfer (NC-FET) differ compared to hospital-controlled monitoring of the ovulation in NC-FET using a hCG trigger? Summary answer We found no differences in obstetric and neonatal outcomes when home-based monitoring versus hospital-controlled monitoring of the ovulation in women undergoing NC-FET. What is known already NC-FET is associated with lower risk of adverse obstetric and neonatal outcomes compared with artificial cycle FET. The question of how to prepare the endometrium for FET, has now gained even more importance and taken on the dimension of safety into account as it should not simply be reduced to the basic question of effectiveness. Study design, size, duration Between April 10, 2018 and April 13, 2022, 1464 women were included in the Antarctica-2 RCT (n = 732 home-based monitoring and n = 732 hospital-controlled monitoring). For this study we performed a follow-up study in order to investigate obstetric and neonatal outcomes of the participating women with live births after the Antarctica-2 trial. Participants/materials, setting, methods We included only singleton livebirths. Main outcomes were gestational age, preterm birth (PTB), very preterm birth (very PTB), birth weight, large for gestational age (LGA) and small for gestational age (SGA). Additional outcomes included: gestational diabetes (GDM), hypertensive-disorders-of-pregnancy (HDP), pre-eclampsia (PE), abnormal placentation (including placenta previa and accrete), hospital admission during pregnancy, congenital anomalies and neonatal death. We calculated risk ratios and absolute risk differences (95% CI) using per protocol analysis. Main results and the role of chance Both studyarms resulted in similar live birth rates. Singleton live birth occured in 146 of 732 women (19.9%) following home-based and in 148 of 732 women (20.2%) following hospital-controlled monitoring. The mean ...