The Incidence and Prevalence of Inflammatory Bowel Disease Continues to Increase in the Faroe Islands – A Cohort Study from 1960 to 2020

• Published in: Journal of Crohn's and Colitis
• Main Authors: Nielsen, Kári Rubek, Midjord, Jóngerð, Nymand Lophaven, Søren, Langholz, Ebbe, Hammer, Turid, Burisch, Johan
• Other Authors: Faroese Research Council, Torben & Alice Frimodts Foundation, Aage & Johanne Louis-Hansens Foundation, the Faroese Foundation, and Betri Foundation
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oxford University Press (OUP) 2023
• Subjects: Faroe Islands; Sandoy
• Online Access: http://dx.doi.org/10.1093/ecco-jcc/jjad155; https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjad155/52191295/jjad155.pdf; https://academic.oup.com/ecco-jcc/article-pdf/18/2/308/56759604/jjad155.pdf

Abstract Background and Aims The highest reported incidence rate of inflammatory bowel disease [IBD], and especially of ulcerative colitis [UC], is found in the Faroe Islands. This study aimed to assess the incidence rate and temporal trends in prevalence over six decades. Methods All incident and prevalent patients diagnosed with IBD between 1960 and 2020 from the nationwide and population-based Faroese IBD cohort were included in this study. All patients fulfilled the Copenhagen Diagnostic Criteria. Results Overall, 873 individuals were diagnosed with IBD during the study period, 559 [64%] with UC, 151 [17%] with Crohn’s disease, and 163 [19%] with IBD unclassified. A total of 59 patients had paediatric-onset IBD. The incidence of IBD continued to increase throughout the study period, as the age-standardized incidence rate started at 8 per 100 000 person-years [py] [European Standard Population, ESP] in 1960–79 and reached 70 by 2010–20. In 2021, the age-standardized period prevalence was 1414 per 100 000 persons. The IBD incidence was unevenly distributed among the islands with Sandoy having the highest rate of 106 per 100 000 py in 2010–2020. Conclusions The incidence of IBD continues to increase in the Faroe Islands, mainly driven by UC. The incidence shows an uneven geographical distribution, which suggests an adverse interaction between unknown environmental factors and genetic traits. The prevalence in 2021 corresponded to 1.3% of the Faroese population. Environmental risk factors are suspected to impact this homogeneous high-risk population; however, the reason for this is unclear.