Competing Risk of Atherosclerotic Risk Factors for Arterial and Venous Thrombosis in a General Population: The Tromsø Study

• Published in: Arteriosclerosis, Thrombosis, and Vascular Biology
• Main Authors: Brækkan, Sigrid K., Hald, Erin M., Mathiesen, Ellisiv B., Njølstad, Inger, Wilsgaard, Tom, Rosendaal, Frits R., Hansen, John-Bjarne
• Format: Article in Journal/Newspaper
• Language: English
• Published: Ovid Technologies (Wolters Kluwer Health) 2012
• Subjects: Cardiology and Cardiovascular Medicine; Tromsø
• Online Access: http://dx.doi.org/10.1161/atvbaha.111.237545; https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.111.237545

Objective— To investigate and compare the impact of traditional atherosclerotic risk factors for the risk of arterial and venous thrombosis, taking into account competing risks. Methods and Results— In 1994–1995, 26,185 subjects were screened in the Tromsø study. Information on traditional atherosclerotic risk factors was obtained by physical examination, blood samples, and questionnaires. Subjects were followed to the first incident event of myocardial infarction (MI) or venous thromboembolism (VTE), or December 31, 2005. During a median of 10.8 years of follow-up, there were 1279 cases of incident MI and 341 VTE events. Advancing age and high body mass index were both associated with MI and VTE. Hazard ratio per decade of age was 2.34 (95% CI: 2.25–2.43) for MI and 1.87 (1.74–2.01) for VTE, and 3 kg/m 2 increase in body mass index was associated with 1.16 (1.11–1.21) and 1.20 (1.12–1.29) increased risk of MI and VTE, respectively. Blood pressure, high levels of triglycerides and total cholesterol, low HDL cholesterol, self-reported diabetes, and smoking were all associated with increased risk of MI but not associated with VTE. Conclusion— Our findings imply that traditional atherosclerotic risk factors, such as smoking, hypertension, dyslipidemia, and diabetes mellitus are not shared by arterial and venous thrombosis.