Changes in Lipid Peroxidation Indexes of the Republic of Sakha (Yakutia) Population Depending on Residence Location

• Published in: IOP Conference Series: Earth and Environmental Science
• Main Authors: Nikolaev, V M, Chirikova, N K, Sofronova, S I
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: IOP Publishing 2021
• Subjects: Arctic; Sakha; Republic of Sakha; Yakutia
• Online Access: http://dx.doi.org/10.1088/1755-1315/670/1/012031; https://iopscience.iop.org/article/10.1088/1755-1315/670/1/012031; https://iopscience.iop.org/article/10.1088/1755-1315/670/1/012031/pdf

Abstract The levels of TBA-active products and antioxidant defense indicators, such as low molecular weight antioxidants (LMWAO from now onward), Vitamin C, catalase, and uric acid, were higher in the new population if compared to indigenous people. When comparing the biochemical parameters by district type, the authors found that in the inhabitants of industrial districts (both new and indigenous), the prooxidant-antioxidant balance (PAB from now onward) was shifted towards higher peroxidation. The increase in antioxidants in the original population was due to higher levels of LMWAO. In the indigenous population it was caused by higher catalase activity. The new population had overstressed adaptive mechanisms, confirmed by higher levels of TBA-active products, Interleukins IL18 and IL6, and AST/ALT ratio. The indigenous residents of arctic districts had significantly lower TBA-active elements, LMWAO, catalase activity, but a higher ascorbic acid level (an endogenous antioxidant) compared to the indigenous population of industrial and agricultural districts. The decrease in lipid peroxidation and the increase in ascorbic acid in the population of Arctic districts may be explained by reduced anthropogenic stress and protein-lipid type nutrition, distinct from the population of other districts.