Lipase-catalyzed synthesis of ethyl ( R )-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods

ABSTRACT Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of t...

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Bibliographic Details
Published in:Bioscience, Biotechnology, and Biochemistry
Main Authors: Ding, Jing, Yang, Zhijun, Zhao, Yu, Fang, Weizhen, Lu, Qun
Other Authors: Fundamental Research Funds for the Central Universities under Grant
Format: Article in Journal/Newspaper
Language:English
Published: Informa UK Limited 2019
Subjects:
Organic Chemistry
Molecular Biology
Applied Microbiology and Biotechnology
General Medicine
Biochemistry
Analytical Chemistry
Biotechnology
Antarc*
Antarctica
Online Access:http://dx.doi.org/10.1080/09168451.2018.1554426
http://academic.oup.com/bbb/article-pdf/83/4/763/36825767/bbb0763.pdf
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Summary:ABSTRACT Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester.

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